Theranostic nanocarriers for drug delivery in central nervous system disorders

Thera4Nerv

Grant no.: (2019/34/H/ST5/00578)


Project meetings

  • Kick of meeting (March 17, 2022)
  • 6M (June 13, 2022)
  • 12M (December 5, 2022)
  • 18M (June 29, 2023)
  • 24M (December 6, 2023)
  • 28M (April 5, 2024)
  • Red Hot Fluorine 19F MRI & SAMS meet Kraków MRI Workshop, 4-6 Dec. 2023, Kraków, organization of the special session devoted for the GRIEG project.
  • 5th Central European Biomedical Congress, May 29 – June 1, 2023, Krakow, Poland, organization of the special session devoted for the GRIEG project.

Conferences and workshops

Talks

2024

K. Stachurski, „New Nanoparticles for Potential Theranostic Applications”, presentation, PEGAN Seminar, INP PAS, 8.05.2024

2023

W. Węglarz, “Magnetic Resonance Imaging at the Institute of Nuclear Physics PAN”, presentation, PEGAN Seminar, INP PAS, 24.05.2023

N. Łopuszyńska, K. Stachurski, T. Didriksen, J. Yang, A. Lind, S. Muller, M. Regulska, M. Leśkiewicz, M. Procner, K. Jasiński, W. Lasoń, P. Warszyński, W. P. Węglarz, “Contrasting properties of hybrid nanosilica and cerium oxide nanoparticles for potential theranostic applications”, Red Hot Fluorine 19F MRI & SAMS meet Kraków MRI Workshop, 4-6 Dec. 2023, Kraków, Poland

J. Yang, A. Lind, T. Didriksen, M. Grandcolas, B. Arstad, P. A. Calvalho, S. Muller, K. Stachurski, N. Łopuszyńska, W. Węglarz, Ch. Le, P. K. Lunde and W.E. Louch, “Synthesis and characterization of multifunctional nanoparticles for potential theranostic applications”, Red Hot Fluorine 19F MRI & SAMS Meet Kraków MRI Workshop 2023, 4-6 December, 2023, Krakow, Poland

M. Szczęch, T. Kruk, A. Hinz, N. Łopuszyńska, K. Jasiński, W.P. Węglarz, M. Bzowska, K. Szczepanowicz „Sequential adsorption of charged nanoobjects as a method of formation of mul-tifunctional theranostic systems”, The 11th International Congress Nanotechnology in Medicine & Biology (BioNanoMed 2023), Graz, Austria, April 2023

M. Szczęch, M. Procner, M. Leśkiewicz, M. Regulska, N. Łopuszyńska, K. Jasiński, W. P. Węglarz, W. Lasoń, P. Warszyński, K. Szczepanowicz „Polymeric-based theranostic nanocarriers to central nervous system therapies”, The 11th International Congress Nanotechnology in Medicine & Biology (BioNanoMed 2023), Graz, Austria, April 2023

J. Yang, A. Lind, T. Didriksen, S. Muller, K. Stachurski, N. Łopuszyńska, W. P. Węglarz „Theranostic nanocarriers for drug delivery in central nervous system disorders”, The 5th Central European Biomedical Congress (CEBC 2023), Krakow, Poland, May-June 2023

W. E. Louch „Understanding cellular structure: function relationships with superresolution microscopy”, The 5th Central European Biomedical Congress (CEBC 2023), Krakow, Poland, May-June 2023

M. Szczęch, T. Kruk, N. Łopuszyńska, K. Stachurski, K. Jasiński, W. P. Węglarz, P. Warszyński, and K. Szczepanowicz, „Synthesis and characterization of polymer-based theranostic nanoparticles containing carnosic acid”, The 5th Central European Biomedical Congress (CEBC 2023), Krakow, Poland, May-June 2023

D. Jantas, A. Roman, M. Szczęch, K. Szczepanowicz, P. Warszyński, W. Lasoń, “Biosafety and neuroprotective potency of polymer-based theranostic nanoparticles containing carnosic acid” The 5th Central European Biomedical Congress (CEBC 2023), Krakow, Poland, May-June 2023

M. Szczęch, M. Procner, M. Leśkiewicz, M. Regulska, N. Łopuszyńska, K. Jasiński, W. P. Węglarz, W. Lasoń, P. Warszyński, and K. Szczepanowicz „Multifunctional Polymeric Nanocarriers of ‘Difficult-to-Deliver’ Active Substances for the Central Nervous System Disorders”, The 3rd International Conference on Bioengineering and Polymer Science (BPC3), Bucharest, Romania, June 2023

2022

M. Szczęch, M. Procner, M. Leskiewicz, N. Lopuszynska, K. Jasinski, W.P. Weglarz, W. Lason, P. Warszynski, K. Szczepanowicz „Polymeric-based Nanocarriers for the Treatment of the Central Nervous System Disorders”, The 36th European Colloid & Interface Society Conference (ECIS 2022), Chania, Crete, Greece, September 2022

A. Lind, J. Yang, T. Didriksen, M. Grandcolas, B. Arstad, K. Szczepanowicz, P. Warszyński, W. P. Węglarz, L. Zhang, “Synthesis of Ceo2/Gd engineered Nanoparticles as Theranostic Nanocarriers” 7th International conference on multifunctional, hybrid & nanomaterials (HYMA 2022), Available at SSRN https://ssrn.com/abstract=4240666, Genoa, Italy, October 2022

M. Szczęch, K. Szczepanowicz „Nanoemulsion Template Method for Preparing Polymeric Nanocarriers”, EUFoam2022, Krakow, Poland, July 2022

Posters

2024

K. Stachurski, N. Łopuszyńska, K. Jasiński, T. Didriksen, J. Yang, A. Lind, S. Mueller, W.P. Węglarz, “MRI Relaxation and Contrast Properties of Cerium Oxide Nanocarriers and Their Theranostic Functionality”, European Molecular Imaging Meeting – EMIM 2024, 12-15 March 2024, Porto, Portugal

B. Grygier, K. Kamińska, K. Szczepanowicz, P. Warszyński, W. Lasoń, A. Basta-Kaim. „Wpływ wolnego edaravonu i edaravonu zamkniętego w nanokapsułkach na hodowle organotypowe hipokampa w modelu udaru niedokrwiennego mózgu”. Dni Farmakologii Polskiej 2024, 26-29 maja 2024, Ustroń-Jaszowiec, Polska

2023

N. Łopuszyńska, K. Szczepanowicz, M. Szczęch, K. Jasiński, K. Stachurski, K. Kalita, P. Warszyński, W.P. Węglarz, „Gadolinium labeled polyelectrolyte nanocapsules for drug delivery and MRI detection – MR investigation of the influence of shell composition on contrasting properties”, Red Hot Fluorine 19F MRI & SAMS meet Kraków MRI Workshop, 4-6 Dec. 2023, Kraków, Poland

L. Szyk-Warszyńska, M. Szczęch, K. Szczepanowicz, P. Warszyński, „Lateral mobility of polymeric core-shell nanocapsules in agarose gels”, 37th conference of European Colloid & Interface Society, 3-8 September 2023, Neapol, Italy

M. Szczęch, M. Procner, N. Łopuszyńska, M. Leśkiewicz, M. Regulska, K. Jasiński, W.P. Węglarz, W. Lasoń, P. Warszyński and K. Szczepanowicz „Functional polymeric nanocarriers to the central nervous system”, 37th European Colloid and Interface Society Conference, , 3–8.09.2023, Neapol, Italy

T. Kruk, M. Szczęch, W. Tomal, M. Rak, K. Łęgowski, M. Bzowska, A. Hinz, S. Łukasiewicz, M. Szuwarzyński, K. Szczepanowicz. „Control of specific/non-specific protein adsorption – functionalization of polyelectrolyte coatings for biomedical application”, 37th European Colloid and Interface Society Conference, 3–8.09.2023, Neapol, Italy

M. Szczęch, M. Procner, N. Łopuszyńska, M. Regulska, M. Leśkiewicz, K. Jasiński, K. Stachurski, B. Pomierny, W.P. Węglarz, W. Lasoń, P. Warszyński and K. Szczepanowicz „Polymer-based theranostic nanocarriers for the central nervous system disorders” th InternaƟonal Workshop on Functional Nanostructured Materials (FuNaM-4) September 26th – 29th, 2023, Krakow, Poland

Kamińska K, Procner M, Regulska M, Leśkiewicz M, Szczęch M, Szczepanowicz K, Lasoń W, Basta-Kaim A. “Polymeric-based nanocarriers for delivery of neuroprotective drugs through blood-brain barrier”. 5th Central European Biomedical Congress, May 29 – June 1, 2023, Krakow, Poland

N. Łopuszyńska, K. Stachurski, K. Jasiński, T. Didriksen, J. Yang, A. Lind, W.P. Węglarz, “In Vitro Investigation of MRI Contrasting Properties of Potential Theranostic Nanocarriers”, World Molecular Imaging Congress – WMIC 2023, September 5-9, 2023, Prague, Czech Republic

K. Stachurski, N. Łopuszyńska, T. Didriksen, J. Yang, A. Lind, W.P. Węglarz, “MRI contrast properties of gadolinium-labeled hybrid nanosilica for potential use in theranostic nanocarriers”, European Molecular Imaging Meeting – EMIM 2023, 14-17 March, Salzburg, Austria

N. Łopuszyńska, K. Szczepanowicz, M. Szczęch, K. Jasiński, K. Stachurski, P. Warszyński, W. Węglarz, “Gadolinium labelled polyelectrolyte theranostic nanocapsules for therapeutic cargo delivery and MRI detection. The influence of shell composition on contrasing properties”, European Molecular Imaging Meeting -EMIM 2023, 14-17 March, Salzburg, Austria W. P. Węglarz, N. Łopuszyńska, K. Jasiński, K. Szczepanowicz, P. Warszyński, “MRI-friendly polyelectrolyte theranostic nanocarriers”, European Molecular Imaging Meeting – EMIM 2023, 14-17 March, Salzburg, Austria

M. Leśkiewicz, K. Kamińska, E. Trojan, M. Procner, M. Szczęch, K. Szczepanowicz, W. Lasoń, A. Basta-Kaim. “Effects of ebselen, edaravone and theranostic nanocarriers on the oxygen-glucose deprivation-induced cell damage: a study in organotypic hippocampal cultures”. 11th IBRO World Congress of Neuroscience, September 9-13.09, 2023, Granada, Spain

K. Kamińska, M. Leśkiewicz, B. Grygier, M. Regulska, M. Szczęch, K. Szczepanowicz, W. Lasoń, P. Warszyński, A. Basta-Kaim, “Effect of carnosic acid-loaded theranostic nanocarriers on the oxygen-glucose deprivation-induced cell damage and inflammatory profile in organotypic hippocampal cultures”. 16th International Congress of Neuroimmunology, August 20-24, 2023, Quebec, Canada

A. Basta-Kaim, K. Kamińska, M. Procner, M. Regulska, M. Leśkiewicz, B. Grygier, B. Korzeniak, M. Szczęch, K. Szczepanowicz, P. Warszynski, W. Lasoń. „Immunomodulatory effect of free and AOT/(PLL/PGA)2-g-PEG nanoparticles loaded carnosic acid in lipopolysaccharide treated organotypic hippocampal cultures.” 16th International Congress of Neuroimmunology, August 20-24, 2023, Quebec, Canada

Jantas D, Warszyński P, Lasoń W. “The study on neuroprotective efficiency of edaravone, ebselen, and carnosic acid in various models of neuronal cell damage: selection the most potent compound for nanoencapsulation”. FENS Regional Meeting, May 3-5, 2023, Algarve, Portugal

2022

N. Łopuszyńska, K. Szczepanowicz, K. Stachurski, M. Szczęch, K. Jasiński, W.P. Węglarz “The Assessment of the Distribution of Drug-loaded Polyelectrolyte Nanocarriers by the 1H or 19F Magnetic Resonance Imaging”, Central European NMR Symposium & Bruker users (CEUM 2022), Warsaw, Poland, September 2022

N. Łopuszyńska, K. Szczepanowicz, M. Szczęch, K. Jasiński, W.P. Węglarz “Effective Detection of Polyelectrolyte Theranostic Nanocarriers by 19F Magnetic Resonance Imaging”, Red Hot Fluorine (19F) MRI meets Small Animal MRI Symposiums (SAMS), Düsseldorf, Germany, June 2022